Key publications

The VAR2CSA malaria protein efficiently retrieves circulating tumor cells in an EpCAM-independent manner. Agerbæk M. Ø., Bang-Christensen S. R., Ming-Hsin Yang, Clausen T. M., Pereira M. A., Sharma S., Ditlev S. B., Nielsen M. A., Choudhary S., Gustavsson T., Sorensen P. H., Meyer T., Propper D., Shamash J., Theander T. G., Aicher A., Daugaard M., Heeschen C., and Salanti A. Nature Communications,  9, Article number: 3279, 2018 (DOI: 10.1038/s41467-018-05793-2).

Targeting Human Cancer by a Glycosaminoglycan Binding Malaria Protein. Salanti A, Clausen TM, Agerbæk MØ, Al Nakouzi N, Dahlbäck M, Oo HZ, Lee S, Gustavsson T, Rich JR, Hedberg BJ, Mao Y, Barington L, Pereira MA, LoBello J, Endo M, Fazli L, Soden J, Wang CK, Sander AF, Dagil R, Thrane S, Holst PJ, Meng L, Favero F, Weiss GJ, Nielsen MA, Freeth J, Nielsen TO, Zaia J, Tran NL, Trent J, Babcook JS, Theander TG, Sorensen PH, Daugaard M. Cancer Cell. 2015 Oct 12;28(4):500-14.

Oncofetal Chondroitin Sulfate Glycosaminoglycans are Key Players in Integrin Signaling and Tumor Cell Motility. Clausen TM, Pereira MA, Al Nakouzi N, Oo HZ, Agerbæk MO, Lee S, Orum-Madsen MS, Kristensen AR, El-Naggar A, Grandgenett PM, Grem JL, Hollingsworth MA, Holst PJ, Theander TG, Sorensen PH, Daugaard M, Salanti A. Mol Cancer Res. 2016 Sep 21.

Real-time and label free determination of ligand binding-kinetics to primary cancer tissue specimens; a novel tool for the assessment of biomarker targeting. Clausen TM, Pereira MA, Oo HZ, Resende M, Gustavson T, Mao Y, Sugiura N, Liew J, Fazli L, Theander TG, Daugaard M, Salanti A. Sens Biosensing Res. 2016 Jul;9:23-30.

Molecular dissection of placental malaria protein VAR2CSA interaction with a chemo-enzymatically synthesized chondroitin sulfate library. Sugiura N, Clausen TM, Shioiri T, Gustavsson T, Watanabe H, Salanti A. Glycoconj J. 2016 Jun 10.

Placental Sequestration of Plasmodium falciparum Malaria Parasites Is Mediated by the Interaction Between VAR2CSA and Chondroitin Sulfate A on Syndecan-1. Ayres Pereira M, Mandel Clausen T, Pehrson C, Mao Y, Resende M, Daugaard M, Riis Kristensen A, Spliid C, Mathiesen L, E Knudsen L, Damm P, G Theander T, R Hansson S, A Nielsen M, Salanti A. PLoS Pathog. 2016 Aug 24;12(8):

Burkitt lymphoma express oncofetal Chondroitin Sulfate without being a reservoir for placental malaria sequestration. Mette Ø. Agerbæk, Marina A. Pereira, Thomas M. Clausen, Caroline Pehrson, Htoo Zarni Oo, Charlotte Spliid, Jamie Rich, Vincent Fung, Francis Nkrumah, Janet Neequaye, Robert J. Bigger, Steven J. Reynolds, Giovanna Tosato, Sheeja T. Pullarkat, Leona W. Ayers, Thor G. Theander, Mads Daugaard, Kishor Bhatia, Morten A. Nielsen, Sam M. Mbulaiteye, and Ali Salanti. International Journal of Cancer. 2017 Apr 1;140(7)